Zelienople is a borough in Butler County, Pennsylvania, 28 miles north of Pittsburgh. The population was 3,812 at the 2010 census. Zelienople is located in southwestern Butler County, situated on the south bank of Connoquenessing Creek, in an area that is rich with coal and iron ore. The elevation is 935 feet above sea level. The borough is bordered by Jackson Township on the north, southeast, and south, and by the borough of Harmony on the northeast. The western border of Zelienople is the Beaver County line.